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发表时间:2017-06-20 阅读次数:

祝贺王怀伟博士的论文发表在Angew上

 

Ligand-Promoted Rhodium(III)-Catalyzed ortho-C−H Amination with Free Amines

 

Ligand development for rhodium(III)-catalyzed C−H activation reactions has largely been limited to cyclopentadienyl (Cp) based scaffolds. 2-Methylquinoline has now been identified as a feasible ligand that can coordinate to the metal center of Cp*RhCl to accelerate the cleavage of the C−H bond of N-pentafluorophenylbenzamides, providing a new structural lead for ligand design. The compatibility of this reaction with secondary free amines and anilines also overcomes the limitations of palladium(II)-catalyzed C−H amination reactions.

 

文章链接:

Angew.Chem. Int.Ed. 2017, 56,7449 –7453

DOI: 10.1002/anie.201703300

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