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发表时间:2019-05-25 阅读次数:

祝贺徐华金同学文章发表于JACS

 

Rh(III)-Catalyzed meta-C–H Alkenylation with Alkynes

 

         

 

       Rh(III)-catalyzed meta-C–H functionalization reactions are still rare. Herein, we report the first example of Rh(III)-catalyzed meta-C–H alkenylation with disubstituted alkynes directed by a U-shaped nitrile template. Exclusive regio-selectivity has been achieved using unsymmetrical aryl and alkyl-disubstituted alkynes to afford synthetically valuable trisubstituted olefins. Propargyl alcohols are also compatible, affording complex allylic alcohols. Notably, transition metal-catalyzed meta-alkenylation with alkynes has not been successful with Pd catalysts.

 

文章链接:https://doi.org/10.1021/jacs.8b11038

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